The LiU Seminar Series in Statistics and Mathematical Statistics
The seminars are typically held bi-weekly on Tuesdays at 15.15-16.15.
For further information, or if you want to be notified about the seminars by e-mail, please contact Mattias Villani.
Tuesday, March 11, 3.15 pm, 2014. Seminar in Mathematical StatisticsEfficient estimation of the number of false positives in high-throughput screening
Holger Rootzén , Mathematical Statistics, Chalmers.
Abstract: This talk is about tail estimation methods to handle false positives in very highly multiple testing problems where testing is done at extreme significance levels and with low degrees of freedom, and where the true null distribution may differ from the theoretical one. We show that the number of false positives, conditional on the total number of positives, approximately has a binomial distribution, and find estimators of its parameter. We also develop methods for estimation of the true null distribution, and techniques to compare it with the theoretical one. Analysis is based on a simple polynomial model for the tail of the distribution of p-values. Asymptotics which motivate the model, properties of the parameter estimators, and model checking tools are provided. The methods are applied to two large genomic studies and an fMRI brain scan experiment.
Location: Kompakta rummet.
Future and Past SeminarsSpring 2014 | Fall 2013 | Spring 2013 | Fall 2012 | Spring 2012 | Fall 2011
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Last updated: 2014-03-06